The game takes place in 2364 or 2365.
The game occurs between season one and two of Star Trek: The Next Generation (1987). Beverly Crusher is the Enterprise's C.M.O. (season one), the crew wears the uniform type that the main characters wore in seasons one and two, Tasha Yar is no longer alive (late season one), and Will Riker has no beard (season one). Geordi La Forge and Worf are wearing the gold uniforms, which did not happen onscreen until season two.