The title of this episode, "insane in the germ brain," is a reference to Cypress Hill's famous song "Insane in the Brain." It's also a nod to the fact that Liv is on a germophobe's brain.
The molecule depicted on the PowerBook bezel during the opening scene is Theobromine; C7H8N4O2,
the alkaloid component of chocolate which is poisonous to dogs and toxic to humans in high doses. As a nonprescription supplement it's used as a diuretic, myocardial stimulant and a vasodilator. As such it doesn't seem to be therapeutic to Isobel's Froelich syndrome which is a pituitary gland malady. One can then assume that this laptop is not Isobel's but loaned by the ME department.
Rose McIver (Liv), David Anders (Blaine), and Giacomo Baessato (Russ Roche) all previously appeared on Once Upon a Time (2011).
Melissa O'Neil (Suki) and Jade Payton (Jordan Gladwell) end up appearing in an episode of The Rookie (2018) (episode Flesh and Blood (2019)), playing Lucy Chen and Dominique Grey respectively. Melissa is a main cast of the show, whilst Jade played a recurring role.