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10/10
Poignant film, pointing out the stark reality of financial toxicity in modern healthcare
4 March 2024
It is harder to find better example of the reality of financial toxicity and insecurity for patients than Hilary Swank's "Ordinary Angels".

Set in Louisville in the 1990s, it stars a struggling alcoholic and hairdresser, Sharon Stevens, who finds purpose in helping a widow, Ed Schmitt, raise money for his daughter Michelle's medical bills. Due to Michelle's biliary atresia requiring a liver transplant and her father's lack of health insurance, the family racks up hundreds of thousands of dollars in medical bills.

Though it was "feel good" movie about the power of community and the human spirit which is highly recommended, with many tear-jerking and heart-warming moments, the underlying theme was very disheartening. These patients are already vulnerable, overwhelmed, and scared from their underlying illness, and it seems many accept financial toxicity as the norm, not realizing that deciding between health and having food on the table should not be a given.

Frankly, very few have the fortune of a relentless advocate such as the character played by Hilary Swank, much less the knowledge or resources to have a fighting chance. Audience members are left hanging, hoping that the movie would show some of the things that doctors and health systems could do better in order to help provide financial assistance.

Nevertheless, this movie does an outstanding job of laying out the facts about this vicious, generational cycle of health-care related financial toxicity. Director Jon Gunn incorporates these themes which come across through the screen very palpably via the characters played by Hilary Swank and Alan Ritchson.

This movie inspires the audience to empower all people to have a chance to regain their health and dignity, by addressing the reality of gaps in care and health-related costs. Essentially, films like this help provide the motivation to make this extraordinary Hollywood tale one day seem nothing more than the ordinary.
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10/10
A humbling story from the Bench to the Bedside and back, harnessing the power of T-cells and authentic human empathy to empower the cancer journey
4 March 2024
This award-winning documentary chronicles the humbling journey of Carl June and his team including Stephan Grupp, David Porter, and many others at the University of Pennsylvania to develop CAR T-cell therapy which would revolutionize treatment for blood cancer.

The audience cannot help but relate to and be touched by Dr. June's humbling reflections of his own life, including his genuine, heart-wrenching emotion about his personal failures, setbacks, and losses, none more than losing his wife at a young age from ovarian cancer. When many would have quit, he kept pressing onward because his mind would not let him stop thinking about how T-cells could be engineered and programmed like soldiers (analogous to his days in the Navy) with HIV lentiviral vectors to kill cancer cells.

Juxtaposed with his journey is that of 5-year-old Emily Whitehead who had just relapsed from acute leukemia, having potentially only weeks left to live. Her parents' courage and persistence resulted in her becoming the first pediatric patient to enroll in an experimental infusion of CAR T-cells. When it caused a life-threatening complication, Dr. June's team discovered that high IL-6 levels could be causing her symptoms, ingeniously administering Tocilizumab, which provided valuable insight into cytokine release syndrome.

Today, Emily remains cancer free and is a freshman studying English at UPenn.

This is a story of bench-to-bedside and back, with so much more on the line than publications or grants. Every scientist and physician dreams about an "Aha" moment like this, and Carl June has a way of openly lending his journey to empower them to feel like they are on the same platform as him, sharing in this victory.

Dr. June humbly admitted that it took empathy and compassion, coupled with divine timing and even luck, to power these scientists to create a novel therapy that has now impacted thousands of lives with not just cancer but other diseases.
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