Dean and Castiel team up to find a Rit Zien, an angel healer, who is easing peoples' suffering by killing them. Sam and Kevin ask Crowley for help in finding a way to open the gates to Heaven.
Sheriff Mills calls Sam and Dean for help with multiple disappearances in the town. Discovering all four victims belonged to the same church chastity group, Sam and Dean decide to infiltrate by joining the group themselves.
Sam and Castiel believe that they found a way to track Gadreel. Dean and Crowley team up to find the first blade, which is in the hands of the biblical Cain.
Abaddon makes a deal with Crowley to stop the Winchesters and recover the first blade. Castiel tries to bring Gadreel to his side in the war against Metatron.