Castiel and Uriel ask Dean to torture Alastair for information. But when Alastair breaks free, Castiel starts to believe that there is a traitor among the angels.
At Sandover Bridge & Iron Inc., Dean is Dean Smith, the buttoned-down director of Sales & Marketing. Sam is Sam Wesson, a cubicle-dwelling tech support guy. What the heck is going on? Or is it what the Hell?
Meet the Winchester boys: Dean, Sam and... Adam. The Winchesters discover they have a younger half-brother, whose mother vanishes just as a long-dormant grave robber renews his ghoulish career.
Castiel has been sent back to Heaven. His human host, Jimmy, tries to regain his life. But the demons won't leave him alone and now his family is at risk. Sam and Dean can help a little, but they're going to need a "miracle" to win.
Dean and Bobby have something frightening locked in Bobby's panic room: Sam, contaminated by demon blood. But as the apocalypse draws nearer, Bobby wants to free Sam to battle on their side.
The brothers prepare to fight the forces of the apocalypse in different camps. While Sam and Ruby hunt down Lilith, Dean joins Castiel and Zachariah to take on Lucifer.
Rufus, an old friend of Bobby's calls, panicked about demons attacking a town in Colorado. Sam and Dean arrive to help, but soon discover things aren't exactly as they seem.
Sam decides to stop hunting but has a hard time after he receives a surprise visit. Dean and Castiel try to find the Archangel Raphael in their bid to stop the Apocalypse.
Dean refuses Sam's efforts to help him battle the Devil, and then wakes up to find himself five years in the future, in a wasteland where Lucifer has begun his endgame by unleashing a virus that transforms humans into zombies.
Sam and Dean head to a small town where people are murdered by famous dead icons. However the brothers come to a dead end when two teenagers reveal they saw Paris Hilton kidnap their friend.
Dean and Sam investigate a series of murders that resemble fairy tales and urban legends; the brothers track down an 11-year-old boy that Castiel deems a serious threat.
Dean and Sam learn that a witch is running a poker game where the currency is life years versus money; Dean tries to intervene when Bobby starts losing the game.
Dean and Sam are at a Supernatural convention where they meet lots of fans of the Supernatural Books. After a while they get the impression that something is not right at the location of the convention.